| S.No. | Title of Project and Sanction Letter No | Sponsor / Funding Agency | Sanctioned Amount (Rs. in Lakhs) | Tenure / Duration | Supervisor / Principal Investigator / Co-Supervisor | Number of Manpower / Research Fellows | Brief Objective |
|---|---|---|---|---|---|---|---|
| In-Progress | |||||||
| 1. | Development of hepcidin-targeted therapies for Anemia. EM/Dev/SG/35/02481/2024 | ICMR | 68.94 | 2025-2027 | Dr. Naveen Kaushal / Dr. Ashok Kumar Dr. Monika Sharma | 1 | 1. In silico studies: i. Modelling of the transporter in various conformations and screening of peptides. ii. Investigating binding affinities of docked peptides to ferroportin 2. In vitro binding of peptide/ferroportin over Hepcidin/Ferroportin binding 3. in vivo evaluation of peptides in maintaining iron homeostasis and amelioration of AI. |
| 2. | Development of Peptide mediated antisense oligonucleotide (PMAsO) based next generation therapeutics for priority pathogens.; R/12-2-22-24-HR/E | DHR-start up | 43.08 | 2024-27 | Dr Ravi Pratap Barnwal / Prof. A. Koul Dr Gurpal Singh | 1 | To develop next generation antibiotics |
| 3. | Development of an eco-friendly, biodegradable antimicrobial packaging material F-147/Sanc/09/2024/899-904 | DST-UT | 2.00 | 2024 | Dr. Avneet Saini / Dr. Simran Preet | 0 | 1. Synthesis and characterization of a biomaterial incorporated packaging material. 2. Evaluation of thermal, structural, optical and mechanical properties of the packaging 3. Estimation of antibacterial, antioxidant and degradation characteristics of the packaging 4. Applicability of the packaging material for preserving the freshness and quality of fruits and vegetables shall be evaluated. |
| 4. | Early detection and monitoring of Glucocorticoid-induced osteoporosis through the identification and validation of new microRNA-based biomarker.; EMDR/SG/13/2023-3498 | ICMR | 60.0 | 2023-26 | Prof Sanjay Kumar Bhadada Dr Gurpal Singh / Dr. Ravi Pratap Barnwal Dr Rimesh Pal | 1 | 0000 |
| 5. | SenseParkinson: Novel fluorescence based DNA-RNA hybrid photosensor for rapid detection of early stage Parkinson’s disease. BT/PR50709/BIC/101/1255/2023 | DBT | 40.0 | 2023-26 | Dr Gurpal Singh / Dr Ravi Pratap Barnwal | 1 | An early detection biosensor for Parkinson’s disease |
| 6. | DNA Aptamer based sirtuin-I nanoformulation in the management of iron deficiency anemia; EMDR/SG/14/2023-0940 | ICMR | 59.0 | 2023-26 | Dr Akhilesh Kumar Dr. Ravi Pratap Barnwal / Dr Gurpal Singh Dr Sonalika | 1 | 00000000000000000 |
| 7. | A fluorescent cyclic peptide conjugated amphipathic-D diastereomers nanotherapeutics for an early detection and treatment of prostate cancer; CRG/2022/000628 | SERB | 60.00 | 2023-26 | Dr Gurpal Singh / Dr Ravi Pratap Barnwal Prof. Sanjay K Bhadada Prof Rakesh Kapoor Prof Santosh Kumar | 1 | To develop early detection cum treatment for prostate cancer |
| 8. | VirusInspired peptide design of monomeric pseudo-alpha helix for the recognition of its RNA targets; 22152 1707/NS | CSIR | 25.4 | 2023-26 | Dr. Ravi Pratap Barnwal / Dr Gurpal Singh | 1 | Development of pseudo helix peptide for different RNAs. |
| 9. | Sense Alzheimer: Novel fluorescence based DNA-RNA hybrid photosensor for rapid detection of early stage Alzheimer’s disease; DST/CSRI/2021/7 | DST CSRI | 93 | 2023-26 | Dr Gurpal Singh / Dr Ravi Pratap Barnwal Dr Udit Soni | 1 | An early detection biosensor for Alzheimer’s disease |
| 10. | Development of gold nanoparticles based lateral flow immunoassay for rapid and early detection of novel biomarker microRNA-204 in type 1 diabetes Ad-hoc/69/2022-ITR | ICMR | 57.4 | 2022-25 | Dr. Ravi Pratap Barnwal / Dr Gurpal Singh Prof. SK Bhadada | 1 | Lateral flow technology will be developed for early stage detection of type 1 diabetes |
| 11. | Ameliorating burn wound management with HNP-1 loaded mesoporous silica nanoparticles: A therapeutic approach SERB/F/9977/2022-2023 | DST SERB | 34.70 | 2023-2026 | Dr. Simran Preet / NA | 1 | To develop a potent topical therapeutic arsenal encompassing a woung healing peptide in a non toxic mesh network targeting the wound environment directly. |
| 12. | Development of a novel antibacterial and antibiofilm coating for biomaterial implants and medical devices 17X/60/2022 | ICMR | 31.30 | 2022 - 2025 | Dr. Avneet Saini / Prof. Kusum Harjai | 1 | • In-silico peptide designing and structural characterization • In-vitro biovalidation of the designed AMPs • Formulation and in-vitro validation of peptide-based biomaterial coating • Establishing the efficacy in in-vivo models |
| 13. | Development of a novel antibacterial and antibiofilm coating for biomaterial implants and medical devices Ad-hoc/60/2022 | ICMR | 50.00 | 2022-2025 | Dr. Avneet Saini / Prof. Kusum Harjai | 1 | 1. In silico peptide designing and structural characterization. 2. In-vitro biovalidation of the designed AMPs. 3. Formulation and in-vitro validation of peptide-based biomaterial coating. 4. Establishing the efficacy in in-vivo models. |
| 14. | Development and biovalidation of a sustainable Antimicrobial peptide conjugated Collagen Scaffold against infectious bacterial pathogens. S/1373/29 | DST UT | 1.20 | 2022 - 2023 | Dr. Avneet Saini / Dr. Ravneet Kaur | 1 | 1. Extraction and characterization of collagen from the scales of exotic carp 2. Development of Antimicrobial peptide conjugated Fish Collagen scaffold 3. In vitro biovalidation of designed scaffold |
| 15. | Development of a human neutrophil peptide (HNP-1) functionalized antimicrobial catheter against Escheria coli mediated urinary tract infection OMI/7/2020-ECD-I | ICMR | 47.00 | 2020-2023 | Dr. Simran Preet / Prof. Praveen Rishi | 1 | To counter the increasing pathogenesis of E.Coli mediated urinary tract infection post insertion of catheters. Hence, a neutrophil peptide coated catheter development for the purpose of E.Coli eradication in the UTIs. |
| 16. | Aptamer conjugated Teriparatide loaded PLGA/PHBV nanocarriers mediated delivery coners an effective treatment for osteoporosis 00 | DHR | 54.00 | 2023-26 | Dr. Ravi Pratap Barnwal / Prof. Sanjay K Bhadada | 1 | A novel targeted treatment and it development for osteoporosis patients |
| 17. | Evaluation of a colon targeted nisin loaded nanoformulation for anticancer therapy 09/2022/907-915 | DST CHD | 1.50 | 2022- 2023 | Dr. Simran Preet / Dr. Avneet Saini | 1 | To formulate a targeted oral delievery cargo system comprising a novel anticancer peptide |
| 18. | Anticancer therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against 7,12- Dimethylbenzen(a)anthracene (DMBA) induced breast cancer IF200149 | DST INSPIRE | 17.00 | 2021-2026 | Dr. Simran Preet / NA | 1 | To establish the anticancer role of human neutrophil peptide against breast cancer in an in vivo system |
| 19. | In-silico Design and Biovalidation of Novel Peptides/Peptidomimetics: An Advanced Approach Towards Anticancer Regimen 99/20/RUSA/25 | RUSA | 3.50 | 1 year | Dr. Avneet Saini / NA | 1 | 1. In- silico design of novel anticancer peptides/peptidomimetics 2. Structural characterization 3. In - vitro validation |
| 20. | Targeted co-delivery of nisin coated cisplatin enriched solid lipid nanoparticles against murine skin cancer 2019/IF190190 | DST INSPIRE | 17.00 | 2020-2025 | Dr. Simran Preet / NA | 1 | To develop solid lipid nanoparticle of an anticancer peptide for the targeted delivery against skin cancer. |
| 21. | Studies on synergistic potential of human intestinal defensin-5 in conjunction with 5-Fluorouracil against 1,2-dimethylhydrazine dihydrochloride induced colon cancer 2020-7280/PROTEOMICS-BMS | ICMR-Direct SRF | 10.22 | 2021-2023 | Dr. Simran Preet / NA | 1 | To establish strong combinatorial role of HD-5 in conjunction with 5-FU against colon cancer in vivo as well as in vitro. |
| 22. | Diagnostic potential of electrical impedance analyser for bone health detection letterno2 | DST | 32.00 | 2020-23 | Prof. M. L. Garg / | 2 | Diagnostic potential of electrical impedance analyser for bone health detection |
| 23. | Serum Metallothionein level determination using a cost-effective impedimetric immunosensor LetterNo | Seed Fund - FKOL | 1.00 | 2020-21 | Prof. M. L. Garg / | 3 | Serum Metallothionein level determination using a cost-effective impedimetric immunosensor |
| 24. | Insilico identification and experimental validation of novel chemical chaperones for preventing amyloid aggregations and rescue cognitive behavior in Alzheimer’s disease rat model DST/CSRI/2018/70 | DST | 48.00 | 2020-2023 | Dr.Tanzeer Kaur / Dr.Neelima Dhingra | 1 | 1. Identification of lead chaperones in silico. 2. Chemical Synthesis of lead chaperones 3. In vitro activity studies 4. In vivo activity studies |
| 25. | Development of a novel nisin loaded organogel system: A topical therapeutic approach against skin cancer EEQ/2017/000540 | DST SERB | 43.00 | 2017- 2020 | Dr. Simran Preet / NA | 1 | To develop a novel topical dual cargo delivery sytem encompassing both peptide and chemodrug against skin cancer |
| 26. | Evaluation of therapeutic potential of human intestinal alpha defensin 5 against colorectal cancer YSS/2015/001275 | DST SERB | 30.50 | 2015- 2018 | Dr. Simran Preet / NA | 1 | To establish HD-5 as a strong anticolon cancer peptide |
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